Wednesday, October 1, 2008

Case report: Acute generalised exanthematous pustulosis and toxic epidermal necrolysis induced by carbamazepine

Dermatology Unit, Singapore General Hospital, Outram Road, Singapore. wuzhuqing@yahoo.com

Abstract:

Acute generalised exanthematous pustulosis and Stevens-Johnson syndrome (toxic epidermal necrolysis spectrum of severe cutaneous drug reactions) are believed to have distinct underlying pathophysiologies. Our patient, a 28-year-old Chinese woman, represents the first known reported case of clinically-consistent and histologically-proven acute generalised exanthematous pustulosis and toxic epidermal necrolysis overlap induced by carbamazepine in the English literature.

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